Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf13tm1Xuzh mutation
(0 available);
any
Fgf13 mutation
(10 available)
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cellular
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• following electroporation with cre recombinase at E14.5, cortical neurons exhibit impaired migration at E18 and P0 compared to in control mice
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nervous system
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• following electroporation with cre recombinase at E14.5, cortical neurons exhibit impaired migration at E18 and P0 compared to in control mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf13tm1Xuzh mutation
(0 available);
any
Fgf13 mutation
(10 available)
Tg(EIIa-cre)C5379Lmgd mutation
(4 available)
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nervous system
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• mice exhibit impaired hippocampal development compared with wild-type mice
• however, positioning of hippocampal neurons is normal by P30
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• mice exhibit loosely packed neurons in the granule cell layer of the dentrate gyrus compared with wild-type mice
• the dentate gyrus exhibit increased neuron numbers in the polymorphic layer compared with in wild-type mice
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• mice exhibit loosely packed neurons in the granule cell layer of the dentrate gyrus compared with wild-type mice
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• neurons exhibit impaired stabilization of microtubule organization in growth cones compared with wild-type cells
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• at E18, Cux1+ neurons are mislocalized in the deep layers of the lateral somatosensory cortex compared to in wild-type mice
• mice exhibit more loosely arrayed neurons with irregular inner and outer borders in the C1 pyramidal layer compared to in wild-type mice
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• reduced Cux1+ cells
• however, the number of Cux1+ neurons are normal at P14 and during adulthood
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• Tbr1+ neurons in the deep layer is increased compared to in wild-type mice
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behavior/neurological
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf13tm1Xuzh mutation
(0 available);
any
Fgf13 mutation
(10 available)
Tg(EIIa-cre)C5379Lmgd mutation
(4 available)
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behavior/neurological
nervous system
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• neurons exhibit impaired stabilization of microtubule organization in growth cones compared with wild-type cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Yql mutation
(0 available);
any
Emx1 mutation
(34 available)
Fgf13tm1Xuzh mutation
(0 available);
any
Fgf13 mutation
(10 available)
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behavior/neurological
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• increased depression-like behavior
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• mice exhibit increased latency to feed in a novelty suppressed feed test compared with wild-type mice
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nervous system
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• at E18, Cux1+ neurons are mislocalized in the deep layers of the lateral somatosensory cortex compared to in wild-type mice
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• most cultured cortical neurons remain multipolar shape unlike control neurons
• axonal branching in the somatosensory cortex and the corticothalamic tracts is increased compared with control mice
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