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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Litaftm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:5433218
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Litaftm1.1Ics/Litaftm1.1Ics Not Specified MGI:5433220


Genotype
MGI:5433220
hm1
Allelic
Composition		 Litaftm1.1Ics/Litaftm1.1Ics
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Litaftm1.1Ics mutation (0 available); any Litaf mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:186411 )
N
• mice exhibit normal peripheral nerve development, maintenance and remyelination
demyelination ( J:186411 )
• accelerated following sciatic nerve crush

immune system
impaired macrophage chemotaxis ( J:186411 )
• under Ccl3-stimulated conditions
increased macrophage cell number ( J:186411 )
• in nerves 5 days following sciatic nerve crush

homeostasis/metabolism
increased susceptibility to injury ( J:186411 )
• following sciatic nerve crush, mice exhibit accelerated demyelination, increased macrophage numbers and axonal sprouting compared with wild-type mice
• however, remyelination is normal

hematopoietic system
impaired macrophage chemotaxis ( J:186411 )
• under Ccl3-stimulated conditions
increased macrophage cell number ( J:186411 )
• in nerves 5 days following sciatic nerve crush

cellular
impaired macrophage chemotaxis ( J:186411 )
• under Ccl3-stimulated conditions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory