Phenotypes associated with this allele

• Allele Symbol: Hspb8^tm1.1Depr
• Allele Name: targeted mutation 1.1, Christophe Depre
• Allele ID: MGI:5433119
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hspb8^tm1.1Depr/Hspb8^tm1.1Depr	B.129-Hspb8^tm1.1Depr	MGI:5433142

Genotype
MGI:5433142

hm1

• Allelic Composition: Hspb8^tm1.1Depr/Hspb8^tm1.1Depr
• Genetic Background: B.129-Hspb8^tm1.1Depr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:186292 )

• myocyte cross sectional area shows limited increase after two weeks of transverse aortic constriction but significantly greater increase in length

abnormal myocardium layer morphology ( J:186292 )

• more of the myocardium is covered by collagen than in controls

thick interventricular septum ( J:186292 )

• thickness is increased after two weeks of transverse aortic constriction more than in controls

• wall stress elevated

cardiac hypertrophy ( J:186292 )

• less hypertrophy develops after two weeks of transverse aortic constriction than in controls

increased heart left ventricle size ( J:186292 )

• end-diastolic diameter is increased after two weeks of transverse aortic constriction more than in controls

abnormal cardiovascular system physiology ( J:186292 )

decreased ventricle muscle contractility ( J:186292 )

• ejection fraction is reduced after two weeks of transverse aortic constriction

increased left ventricle diastolic pressure ( J:186292 )

• end-diastolic pressure elevated after two weeks of transverse aortic constriction more than in controls

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:186292 )

• mortality rate during transverse aortic constriction is double that of controls

respiratory system

increased lung weight ( J:186292 )

• lung weight/tibia weight ratio is increased after two weeks of transverse aortic constriction

cellular

abnormal cellular respiration ( J:186292 )

• ADP/oxygen and respiratory control ratio of mitochondria are significantly reduced relative to controls

immune system

decreased circulating interleukin-6 level ( J:186292 )

• plasma IL6 levels are reduced under basal conditions

• transverse aortic constriction causes further reduction in IL6 levels

muscle

abnormal myocardium layer morphology ( J:186292 )

• more of the myocardium is covered by collagen than in controls

decreased ventricle muscle contractility ( J:186292 )

• ejection fraction is reduced after two weeks of transverse aortic constriction

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:186292 )

• plasma IL6 levels are reduced under basal conditions

• transverse aortic constriction causes further reduction in IL6 levels

growth/size/body

cardiac hypertrophy ( J:186292 )

• less hypertrophy develops after two weeks of transverse aortic constriction than in controls

increased lung weight ( J:186292 )

• lung weight/tibia weight ratio is increased after two weeks of transverse aortic constriction