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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxp4tm2.1Eem
targeted mutation 2.1, Edward E Morrisey
MGI:5433099
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5433105
cn2
 		Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5433106
cn3
 		Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Scgb1a1tm1(icre)Fjd/Scgb1a1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5433107


Genotype
MGI:5433105
cn1
Allelic
Composition		 Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp4tm2.1Eem mutation (0 available); any Foxp4 mutation (89 available)
Shhtm1(EGFP/cre)Cjt mutation (2 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:185603 )
N
• mice exhibit normal prenatal and postnatal survival




Genotype
MGI:5433106
cn2
Allelic
Composition		 Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1tm1.1Pwt mutation (1 available); any Foxp1 mutation (77 available)
Foxp4tm2.1Eem mutation (0 available); any Foxp4 mutation (89 available)
Shhtm1(EGFP/cre)Cjt mutation (2 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:185603 )
• mice die within minutes of birth of apparent respiratory distress

respiratory system
decreased club cell number ( J:185603 )
• in the proximal airways at E18.5
abnormal respiratory system development ( J:185603 )
• as determined by marker expression, mice exhibit an increase in ciliated epithelial cell differentiation compared with control mice




Genotype
MGI:5433107
cn3
Allelic
Composition		 Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Scgb1a1tm1(icre)Fjd/Scgb1a1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1tm1.1Pwt mutation (1 available); any Foxp1 mutation (77 available)
Foxp4tm2.1Eem mutation (0 available); any Foxp4 mutation (89 available)
Scgb1a1tm1(icre)Fjd mutation (1 available); any Scgb1a1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal respiratory system development ( J:185603 )
• mice exhibit an increase in goblet cell differentiation compared with control mice
abnormal respiratory system physiology ( J:185603 )
• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice

homeostasis/metabolism
increased susceptibility to injury ( J:185603 )
• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory