Phenotypes associated with this allele

• Allele Symbol: Tmem100^tm2.1Ysai
• Allele Name: targeted mutation 2.1, Yoshihiko Saito
• Allele ID: MGI:5432905
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tmem100^tm1.1Ysai/Tmem100^tm2.1Ysai Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * SJL	MGI:5432907

Genotype
MGI:5432907

cn1

• Allelic Composition: Tmem100^tm1.1Ysai/Tmem100^tm2.1Ysai; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Impaired angiogenesis in Tmem100^tm1.1Ysai/Tmem100^tm2.1Ysai Tg(Tek-cre)1Ywa/0 embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:186473 )

• around E11.0

cardiovascular system

abnormal blood vessel morphology ( J:186473 )

• vascular defects are very similar to those in germline null mice

abnormal dorsal aorta morphology ( J:186473 )

• highly dilated or narrow

poor arterial differentiation ( J:186473 )

• expression analysis indicates defects in arterial differentiation

abnormal vitelline vasculature morphology ( J:186473 )

• absence of major vessels at E10.5

abnormal trabecula carnea morphology ( J:186473 )

• poorly formed

pericardial effusion ( J:186473 )

• at E10.5

embryo

abnormal vitelline vasculature morphology ( J:186473 )

• absence of major vessels at E10.5

embryonic growth retardation ( J:186473 )

• at E10.5

abnormal visceral yolk sac morphology ( J:186473 )

• detachment of endodermal and mesodermal layers

growth/size/body

embryonic growth retardation ( J:186473 )

• at E10.5

homeostasis/metabolism

pericardial effusion ( J:186473 )

• at E10.5

muscle

abnormal trabecula carnea morphology ( J:186473 )

• poorly formed