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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Calhm1tm1Geno
targeted mutation 1, Genoway
MGI:5432529
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Calhm1tm1Geno/Calhm1tm1Geno involves: 129 MGI:6307102
hm2
 		Calhm1tm1Geno/Calhm1tm1Geno involves: 129 * C57BL/6 MGI:5432534


Genotype
MGI:6307102
hm1
Allelic
Composition		 Calhm1tm1Geno/Calhm1tm1Geno
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calhm1tm1Geno mutation (0 available); any Calhm1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal gustatory system physiology ( J:269649 )
• type II taste bud cells lack voltage-activated nonselective currents




Genotype
MGI:5432534
hm2
Allelic
Composition		 Calhm1tm1Geno/Calhm1tm1Geno
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calhm1tm1Geno mutation (0 available); any Calhm1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron physiology ( J:186424 )
• cortical neurons exhibit altered electrical properties compared with wild-type cells
• following calcium removal and addback, cultured cortical neurons exhibit less robust calcium elevation compared with wild-type cells
• input resistance is completely insensitive to reduction of calcium unlike in wild-type neurons
• reduction of calcium failed to enhance membrane excitability unlike in wild-type neurons
• the current required to maintain -75 mV is larger than in wild-type cortical neurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory