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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Egln3tm2Fong
targeted mutation 2, Guo-Hua Fong
MGI:5431993
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Egln1tm1.1Brei/Egln1tm1.1Brei
Egln3tm2Fong/Egln3tm2Fong
Tg(CD68-icre)1Bwlx/0 		involves: 129S6/SvEvTac * C57BL/6 MGI:5568402
cn2
 		Egln1tm2Fong/Egln1tm2Fong
Egln2tm2Fong/Egln2tm2Fong
Egln3tm2Fong/Egln3tm2Fong
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: 129S6/SvEvTac * C57BL/6NCr * CD-1 MGI:5432008


Genotype
MGI:5568402
cn1
Allelic
Composition		 Egln1tm1.1Brei/Egln1tm1.1Brei
Egln3tm2Fong/Egln3tm2Fong
Tg(CD68-icre)1Bwlx/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1.1Brei mutation (0 available); any Egln1 mutation (23 available)
Egln3tm2Fong mutation (1 available); any Egln3 mutation (26 available)
Tg(CD68-icre)1Bwlx mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
polycythemia ( J:194598 )
• mice display severe erythrocytosis

mortality/aging
neonatal lethality ( J:194598 )
• animals start dying shortly after birth




Genotype
MGI:5432008
cn2
Allelic
Composition		 Egln1tm2Fong/Egln1tm2Fong
Egln2tm2Fong/Egln2tm2Fong
Egln3tm2Fong/Egln3tm2Fong
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCr * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm2Fong mutation (1 available); any Egln1 mutation (23 available)
Egln2tm2Fong mutation (1 available); any Egln2 mutation (19 available)
Egln3tm2Fong mutation (1 available); any Egln3 mutation (26 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory