All Phenotypes Drp2<tm1.1Brp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Drp2^tm1.1Brp
targeted mutation 1.1, Peter J Brophy
MGI:5431939

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Drp2^tm1.1Brp/Y Cnp^tm1(cre)Kan/Cnp⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5431958

Allelic Composition	Drp2^tm1.1Brp/Y Cnp^tm1(cre)Kan/Cnp⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnp^tm1(cre)Kan mutation (0 available); any Cnp mutation (26 available)
Drp2^tm1.1Brp mutation (0 available); any Drp2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:185953 )

N	• mice do not exhibit any functional defects in nerves

abnormal Schwann cell morphology ( J:185953 )

• Cajal bands are disrupted

• increased Schmidt-Lanterman incisures at 6 weeks

increased Schwann cell number ( J:185953 )

• supernumerary

abnormal myelin sheath morphology ( J:185953 )

• myelin outfoldings, focal hypermyelination and onion bulbs with thin myelin

• defects increase with time

hypermyelination ( J:185953 )

• focal

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