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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnq1ot1tm2.1Ckan
targeted mutation 2.1, Chandrasekhar Kanduri
MGI:5431827
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Kcnq1ot1tm2.1Ckan/Kcnq1ot1+
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SD7 MGI:5431828
cn2
 		Kcnq1ot1tm2.1Ckan/Kcnq1ot1+
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7 MGI:5431829


Genotype
MGI:5431828
cn1
Allelic
Composition		 Kcnq1ot1tm2.1Ckan/Kcnq1ot1+
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SD7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq1ot1tm2.1Ckan mutation (0 available); any Kcnq1ot1 mutation (0 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal imprinting ( J:185569 )
• loss of imprinting of ubiquitously imprinted genes when the Kcnq1ot1 allele is inherited paternally
• no alteration of imprinting status when the Kcnq1ot1 allele is inherited maternally

growth/size/body
decreased body weight ( J:185569 )
• at 4 weeks of age when the Kcnq1ot1 allele is inherited maternally
postnatal growth retardation ( J:185569 )




Genotype
MGI:5431829
cn2
Allelic
Composition		 Kcnq1ot1tm2.1Ckan/Kcnq1ot1+
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SD7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq1ot1tm2.1Ckan mutation (0 available); any Kcnq1ot1 mutation (0 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA methylation ( J:185569 )
• loss of methylation in the somatic differentially methylated regions following tamoxifen treatment at E8.5 when the Kcnq1ot1 allele is inherited paternally
abnormal imprinting ( J:185569 )
• loss of imprinting of ubiquitously imprinted genes following tamoxifen treatment at E8.5 when the Kcnq1ot1 allele is inherited paternally
• however, silencing of placental-specific imprinted genes is variably maintained
• no alteration of imprinting status when the Kcnq1ot1 allele is inherited maternally




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory