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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1.1Wgu
targeted mutation 1.1, Wei Gu
MGI:5431727
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm1.1Wgu/Trp53tm1.1Wgu involves: 129S6/SvEvTac * C57BL/6 MGI:5431825


Genotype
MGI:5431825
hm1
Allelic
Composition		 Trp53tm1.1Wgu/Trp53tm1.1Wgu
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1.1Wgu mutation (0 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:186159 )
N
• mouse embryonic fibroblasts (MEFs) exhibit normal cell-cycle arrest and senescence
decreased cellular sensitivity to gamma-irradiation ( J:186159 )
• in thymocytes
• in the testes, intestines and spleen
decreased thymocyte apoptosis ( J:186159 )
• gamma-irradiation-induced apoptosis is virtually abrogated
increased fibroblast proliferation ( J:186159 )
• slightly in mouse embryonic fibroblasts

neoplasm
neoplasm ( J:186159 )
N
• mice exhibit normal spontaneous tumors development

immune system
decreased thymocyte apoptosis ( J:186159 )
• gamma-irradiation-induced apoptosis is virtually abrogated

hematopoietic system
decreased thymocyte apoptosis ( J:186159 )
• gamma-irradiation-induced apoptosis is virtually abrogated

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:186159 )
• gamma-irradiation-induced apoptosis is virtually abrogated




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory