All Phenotypes Rnaseh2b<tm1Hgu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rnaseh2b^tm1Hgu
targeted mutation 1, MRC Human Genetics Unit
MGI:5431529

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnaseh2b^tm1Hgu/Rnaseh2b^tm1Hgu	involves: 129P2/OlaHsd * C57BL/6J	MGI:5431540

Allelic Composition	Rnaseh2b^tm1Hgu/Rnaseh2b^tm1Hgu
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2b^tm1Hgu mutation (0 available); any Rnaseh2b mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality ( J:186180 )

• crosses between heterozygotes fail to produce offspring

embryo

caudal body truncation ( J:186180 )

embryonic growth retardation ( J:186180 )

• through gastrulation

decreased embryo size ( J:186180 )

• reduced embryo height and width at E7.5

• reduced in size through gastrulation

impaired somite development ( J:186180 )

• few or very small postcervical somites

abnormal allantois morphology ( J:186180 )

growth/size/body

embryonic growth retardation ( J:186180 )

• through gastrulation

decreased embryo size ( J:186180 )

• reduced embryo height and width at E7.5

• reduced in size through gastrulation

cellular

abnormal cell morphology ( J:186180 )

• by E11.5, mice exhibit increased numbers of cells with condensed or fragmented nuclei compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24