All Phenotypes Ak7<Tg(tetO-Hmox1)67Sami> MGI Mouse

mortality/aging

premature death ( J:186062 )

• half of all mice die between 3 and 4 weeks of age

• however, mice with milder ventricular expansion survive more than 6 weeks

reproductive system

reproductive system phenotype ( J:186062 )

N	• female mice exhibit normal fertility

azoospermia ( J:186062 )

• by 42 days, mice exhibit almost complete absence of mature spermatids and spermatozoa in the seminiferous tubules and mature sperm in the epididymis

abnormal sperm head morphology ( J:186062 )

male infertility ( J:186062 )

respiratory system

abnormal respiratory motile cilium morphology ( J:186062 )

• microtubule defects

abnormal respiratory motile cilium physiology ( J:186062 )

• reduced cilia beat frequency

respiratory system inflammation ( J:186062 )

• mice sensitized with ovalbumin exhibit moderate signs of peribronchial and perivascular inflammation unlike wild-type mice

• mice mice sensitized and challenged with ovalbumin exhibit exacerbated inflammatory responses and airway remodeling compared with wild-type mice

rhinitis ( J:186062 )

• mice exhibit excess mucus with polymorphonuclear leukocytes in the paranasal sinuses unlike in wild-type mice

nervous system

hydrocephaly ( J:186062 )

• after birth

enlarged lateral ventricles ( J:186062 )

• expanded

thin cerebral cortex ( J:186062 )

abnormal cerebellum morphology ( J:186062 )

• compressed

growth/size/body

growth/size/body region phenotype ( J:186062 )

N	• mice do not exhibit situs invertus

postnatal growth retardation ( J:186062 )

renal/urinary system

renal/urinary system phenotype ( J:186062 )

N	• mice do not exhibit polycystic kidney disease

immune system