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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		P2rx5tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:5430769
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		P2rx5tm1Lex/P2rx5tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:5430802


Genotype
MGI:5430802
hm1
Allelic
Composition		 P2rx5tm1Lex/P2rx5tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx5tm1Lex mutation (2 available); any P2rx5 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:82809 )
• decreased peripheral blood CD8+ lymphocytes

immune system
decreased CD8-positive, alpha-beta T cell number ( J:82809 )
• decreased peripheral blood CD8+ lymphocytes

behavior/neurological
impaired cued conditioning behavior ( J:82809 )
• impaired learning/memory during trace aversive conditioning
increased exploration in new environment ( J:82809 )
• increased exploratory behavior during open field testing




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory