About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ruvbl2M1Btlr
mutation 1, Bruce Beutler
MGI:5428996
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ruvbl2M1Btlr/Ruvbl2M1Btlr involves: C57BL/6J MGI:5429176
ht2
 		Ruvbl2M1Btlr/Ruvbl2+ involves: C57BL/6J MGI:5429177


Genotype
MGI:5429176
hm1
Allelic
Composition		 Ruvbl2M1Btlr/Ruvbl2M1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ruvbl2M1Btlr mutation (1 available); any Ruvbl2 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, complete penetrance ( J:185495 )
• no mice are recovered




Genotype
MGI:5429177
ht2
Allelic
Composition		 Ruvbl2M1Btlr/Ruvbl2+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ruvbl2M1Btlr mutation (1 available); any Ruvbl2 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit a normal response to NP-Ficoll
• B cell development is normal
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased T cell number ( J:185495 )
• T cell deficiency
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgG1 level ( J:185495 )
• 7 days following NP-CGG immunization
• however, levels were normal by day 14
decreased IgM level ( J:185495 )
• 7 days following NP-CGG immunization
• however, levels were normal by day 14

pigmentation

hematopoietic system
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased T cell number ( J:185495 )
• T cell deficiency
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgG1 level ( J:185495 )
• 7 days following NP-CGG immunization
• however, levels were normal by day 14
decreased IgM level ( J:185495 )
• 7 days following NP-CGG immunization
• however, levels were normal by day 14

integument

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory