Phenotypes associated with this allele

• Allele Symbol: Tg(Pklr-HRAS*G12V)23Ak
• Allele Name: transgene insertion 23, Axel Kahn
• Allele ID: MGI:5428752
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Pklr-HRAS*G12V)23Ak/0	involves: C57BL/6 * DBA/2	MGI:5428764

Genotype
MGI:5428764

tg1

• Allelic Composition: Tg(Pklr-HRAS*G12V)23Ak/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased kidney tumor incidence ( J:44803 )

• kidneys of mutants fed a carbohydrate-rich diet show a few small tumors

abnormal renal tubule morphology ( J:44803 )

• kidneys of mutants fed a carbohydrate-rich diet show tubular distensions, multiple cortical areas of tubular proliferation and a few small tumors

neoplasm

increased hepatocellular carcinoma incidence ( J:44803 )

• mutants fed a carbohydrate-rich diet develop hepatocarcinomas; hepatocarcinomas are seen in all mutants by 6 months of age

• tumor cells show anisocytosis, anisocaryosis and large eosinophilic cytoplasm containing strongly eosinophilic inclusions

increased hepatoma incidence ( J:44803 )

• mutants fed a carbohydrate-rich diet develop hepatomas associated with kidney lesions

increased kidney tumor incidence ( J:44803 )

• kidneys of mutants fed a carbohydrate-rich diet show a few small tumors

liver/biliary system

increased hepatocellular carcinoma incidence ( J:44803 )

• mutants fed a carbohydrate-rich diet develop hepatocarcinomas; hepatocarcinomas are seen in all mutants by 6 months of age

• tumor cells show anisocytosis, anisocaryosis and large eosinophilic cytoplasm containing strongly eosinophilic inclusions

increased hepatoma incidence ( J:44803 )

• mutants fed a carbohydrate-rich diet develop hepatomas associated with kidney lesions