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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stk38tm1Hem
targeted mutation 1, Brian A Hemmings
MGI:5428694
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stk38tm1Hem/Stk38tm1Hem involves: 129P2/Ola * C57BL/6 MGI:5428695
ht2
 		Stk38tm1Hem/Stk38+ involves: 129P2/Ola * C57BL/6 MGI:5428697


Genotype
MGI:5428695
hm1
Allelic
Composition		 Stk38tm1Hem/Stk38tm1Hem
Genetic
Background		 involves: 129P2/Ola * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk38tm1Hem mutation (0 available); any Stk38 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:185408 )
• high grade in aged mice
• in ENU-treated mice

cellular
decreased sensitivity to induced cell death ( J:185408 )
• in response to etoposide
decreased thymocyte apoptosis ( J:185408 )
• following cytokine withdrawal

immune system
abnormal T cell physiology ( J:185408 )
• following cytokine withdrawal, thymocytes exhibit increased survival compared with wild-type cells
decreased thymocyte apoptosis ( J:185408 )
• following cytokine withdrawal

homeostasis/metabolism

hematopoietic system
abnormal T cell physiology ( J:185408 )
• following cytokine withdrawal, thymocytes exhibit increased survival compared with wild-type cells
decreased thymocyte apoptosis ( J:185408 )
• following cytokine withdrawal

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:185408 )
• following cytokine withdrawal
increased T cell derived lymphoma incidence ( J:185408 )
• high grade in aged mice
• in ENU-treated mice




Genotype
MGI:5428697
ht2
Allelic
Composition		 Stk38tm1Hem/Stk38+
Genetic
Background		 involves: 129P2/Ola * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk38tm1Hem mutation (0 available); any Stk38 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:185408 )
• high grade in aged mice
• in ENU-treated mice

cellular
decreased sensitivity to induced cell death ( J:185408 )
• in response to etoposide

homeostasis/metabolism

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:185408 )
• high grade in aged mice
• in ENU-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory