Phenotypes associated with this allele

• Allele Symbol: Tmsb4x^tm1.1Chen
• Allele Name: targeted mutation 1.1, Ju Chen
• Allele ID: MGI:5427989
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmsb4x^tm1.1Chen/Tmsb4x^tm1.1Chen	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:5427997
ot2	Tmsb4x^tm1.1Chen/Y	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:5427998

Genotype
MGI:5427997

hm1

• Allelic Composition: Tmsb4x^tm1.1Chen/Tmsb4x^tm1.1Chen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:185264 )

♀N • in adult homozygous mice, cardiac function, capillary density, expression of key cardiac fetal and angiogenic genes, epicardial marker expression, and extracellular matrix deposition were indistinguishable from that of controls

normal phenotype

no abnormal phenotype detected ( J:185264 )

♀ • Background Sensitivity: homozygous mice are viable and fertile, and exhibit normal heart and blood vessel formation; in addition, no differences were seen on a congenic C57BL/6 genetic background

Genotype
MGI:5427998

ot2

• Allelic Composition: Tmsb4x^tm1.1Chen/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

normal phenotype

no abnormal phenotype detected ( J:185264 )

♂ • Background Sensitivity: homozygous mice are viable and fertile, and exhibit normal heart and blood vessel formation; in addition, no differences were seen on a congenic C57BL/6 genetic background

cardiovascular system

cardiovascular system phenotype ( J:185264 )

♂N • in adult homozygous mice, cardiac function, capillary density, expression of key cardiac fetal and angiogenic genes, epicardial marker expression, and extracellular matrix deposition were indistinguishable from that of controls