All Phenotypes Gata4<tm1Grg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata4^tm1Grg
targeted mutation 1, Vidu Garg
MGI:5427934

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata4^tm1Grg/Gata4^tm1Grg	involves: 129 * C57BL/6	MGI:5427935
ht2	Gata4^tm1Grg/Gata4⁺	involves: 129 * C57BL/6	MGI:5427936
cn3	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Nkx2-5-cre)9Eno/0	involves: 129 * C57BL/6	MGI:5427940
cn4	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0	involves: 129 * C57BL/6 * FVB/N	MGI:5427939
cn5	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Tek-cre)1Ywa/0	involves: 129 * C57BL/6 * SJL	MGI:5427937

Allelic Composition	Gata4^tm1Grg/Gata4^tm1Grg
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1Grg mutation (1 available); any Gata4 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Growth retardation and a thin myocardium in Gata4^tm1Grg/Gata4^tm1Grg mice

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:185124 )

• die between E10.5 and E11.5

growth/size/body

embryonic growth retardation ( J:185124 )

• severe growth retardation at E9.5 and E10.5

cardiovascular system

thin myocardium ( J:185124 )

• severe thinning at E10.5

delayed heart looping ( J:185124 )

• some embryos show delayed or incomplete looping at E9.5 and E10.5

thin ventricular wall ( J:185124 )

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5

cellular

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5

embryo

embryonic growth retardation ( J:185124 )

• severe growth retardation at E9.5 and E10.5

muscle

thin myocardium ( J:185124 )

• severe thinning at E10.5

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E9.5

Allelic Composition	Gata4^tm1Grg/Gata4⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1Grg mutation (1 available); any Gata4 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Atrial septal defects and semilunar valve stenosis in Gata4^tm1Grg/Gata4⁺ mice

cardiovascular system

aorta stenosis ( J:185124 )

• in 4 of 12 mutants

thin ventricle myocardium compact layer ( J:185124 )

abnormal heart atrium morphology ( J:185124 )

• thin

atrial septal defect ( J:185124 )

patent cardiac foramen ovale ( J:185124 )

• increase in the frequency of mice with intermittent shunting of blood between the atria

thick aortic valve cusps ( J:185124 )

• thickened aortic valve leaflets

thick pulmonary valve cusps ( J:185124 )

• thickened pulmonary valve leaflets

pulmonary valve stenosis ( J:185124 )

• in 2 of 12 mutants

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

cellular

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

muscle

thin ventricle myocardium compact layer ( J:185124 )

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atrial heart septal defect 2		DOID:0110107	OMIM:607941	J:185124

Allelic Composition	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Nkx2-5-cre)9Eno/0
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1.1Wtp mutation (0 available); any Gata4 mutation (37 available)
Gata4^tm1Grg mutation (1 available); any Gata4 mutation (37 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Growth retardation and myocardial thinning in Gata4^tm1.1Wtp/Gata4^tm1Grg Tg(Nkx2-5-cre)9Eno/0 mice

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:185124 )

• at E10.5

growth/size/body

embryonic growth retardation ( J:185124 )

• severe

cardiovascular system

thin myocardium ( J:185124 )

embryo

embryonic growth retardation ( J:185124 )

• severe

muscle

thin myocardium ( J:185124 )

Allelic Composition	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hearts of Gata4^tm1.1Wtp/Gata4^tm1Grg Tg(Myh6-cre)2182Mds/0 mice appear normal

normal phenotype

no abnormal phenotype detected ( J:185124 )

• viable with no signs of embryonic growth retardation or myocardial thinning

Allelic Composition	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hypocellular endocardial cushions in Gata4^tm1.1Wtp/Gata4^tm1Grg Tg(Tek-cre)1Ywa/0 mice

cardiovascular system

abnormal atrioventricular cushion morphology ( J:185124 )

• hypocellular endocardial cushions are noted at E10.5

• however, no myocardial thinning is seen

growth/size/body

growth/size/body region phenotype ( J:185124 )

N	• viable with no signs of embryonic growth retardation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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