Phenotypes associated with this allele

• Allele Symbol: Mc2r^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:5427678
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mc2r^tm1Dgen/Mc2r^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6J	MGI:5427836

Genotype
MGI:5427836

hm1

• Allelic Composition: Mc2r^tm1Dgen/Mc2r^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased brown fat lipid droplet number ( J:82809 )

• Brown adipose tissue, decreased cytoplasmic lipid vacuolation

decreased percent body fat/body weight ( J:82809 )

• low fat % in homozygous mutant females

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:82809 )

• decreased metrazol response threshold

increased anxiety-related response ( J:82809 )

• decreased time immobile on tail suspension test

increased locomotor activity ( J:82809 )

• increased total distance traveled in open field test

endocrine/exocrine glands

adrenal cortical hyperplasia ( J:82809 )

adrenal gland hypoplasia ( J:82809 )

• cortex and medulla

nervous system

increased susceptibility to pharmacologically induced seizures ( J:82809 )

• decreased metrazol response threshold