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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grm8tm1Dgen
targeted mutation 1, Deltagen
MGI:5427675
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grm8tm1Dgen/Grm8tm1Dgen involves: 129P2/OlaHsd * C57BL/6J MGI:5427829


Genotype
MGI:5427829
hm1
Allelic
Composition		 Grm8tm1Dgen/Grm8tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm8tm1Dgen mutation (2 available); any Grm8 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor behavior ( J:82809 )
• homozygous mutant animals displayed a statistically significant increase in total distance traveled in the open field test, relative to wild-type animals

nervous system
decreased prepulse inhibition ( J:82809 )
• homozygous mutant animals displayed a statistically significant decrease in Prepulse Inhibition (PPI) with a 100dB prepulse




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory