Analysis Tools
adipose tissue
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• fat percent and total tissue mass, low, homozygous females and males, 300 days
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behavior/neurological
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• mutant mice required a larger dose of metrazol to induce a first twitch and tonic/clonic seizure than wild-type mice
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• mutant mice required a smaller dose than wild-types to induce tonic extension
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• homozygous mutants were significantly impaired on the Rotarod test compared to age- and sex-matched wild-type control mice
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• homozygous mutants displayed an increased response latency trend during both the Hot Plate and Tail Flick tests
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growth/size/body
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• body weights, low, homozygous females, 49 days, and homozygous females and males, 300 days
• tendency for low body weight, and low body weight to body length ratio, homozygous females and males
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nervous system
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• mutant mice required a larger dose of metrazol to induce a first twitch and tonic/clonic seizure than wild-type mice
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• mutant mice required a smaller dose than wild-types to induce tonic extension
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