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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bdnftm1.1Krj
targeted mutation 1.1, Kevin R Jones
MGI:5427360
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bdnftm1.1Krj/Bdnftm1.1Krj involves: 129S2/SvPas MGI:5617025
ht2
 		Bdnftm1.1Krj/Bdnf+ involves: 129S2/SvPas * C57BL/6 MGI:5427384


Genotype
MGI:5617025
hm1
Allelic
Composition		 Bdnftm1.1Krj/Bdnftm1.1Krj
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1.1Krj mutation (0 available); any Bdnf mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal sensory neuron innervation pattern ( J:192549 )
• at E13, female mice exhibit very few sensory neurons associated with the mammary gland rudiments unlike wild-type mice




Genotype
MGI:5427384
ht2
Allelic
Composition		 Bdnftm1.1Krj/Bdnf+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1.1Krj mutation (0 available); any Bdnf mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:184139 )
N
• whole apical and basal spine density in the visual cortex is normal at 3 weeks of age
• distal segment density of both basal and apical dendrites is normal at 4 months of age
abnormal dendritic spine morphology ( J:184139 )
• spine head diameter fails to increase as it does in controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory