Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc2tm1.1Ajg mutation
(1 available);
any
Tmc2 mutation
(42 available)
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hearing/vestibular/ear
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• partially resistant to gentamicin induced toxicity with hair cell loss confined to the basal end of the cochlea
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behavior/neurological
nervous system
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• partially resistant to gentamicin induced toxicity with hair cell loss confined to the basal end of the cochlea
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hearing/vestibular/ear
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• negligible acceleration gain values at 2-3 months of age during high-acceleration, whole-body rotations in darkness
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• first detected at approximately P9
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• first detected at P5 and P7 in the basal and apical cochlear turns, respectively
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• utricle hair cells lack detectable FM1-43 uptake indicting severely impaired mechanotransduction channel activity
• utricle hair cell bundles are resistant to gentamicin induced toxicity due to impaired uptake of gentamicin
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• hair cells lack detectable FM1-43 uptake indicting severely impaired mechanotransduction channel activity
• hair cell bundles are resistant to gentamicin induced toxicity due to impaired uptake of gentamicin
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• basal outer hair cells lack mechanotransduction currents
• however, tip-links appear to be intact
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• increased ABR threshold at all frequencies tested
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behavior/neurological
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• early postnatal pups lack the ability to right from a supine position
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• negligible acceleration gain values at 2-3 months of age during high-acceleration, whole-body rotations in darkness
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nervous system
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• first detected at approximately P9
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• first detected at P5 and P7 in the basal and apical cochlear turns, respectively
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• utricle hair cells lack detectable FM1-43 uptake indicting severely impaired mechanotransduction channel activity
• utricle hair cell bundles are resistant to gentamicin induced toxicity due to impaired uptake of gentamicin
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• hair cells lack detectable FM1-43 uptake indicting severely impaired mechanotransduction channel activity
• hair cell bundles are resistant to gentamicin induced toxicity due to impaired uptake of gentamicin
|
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• basal outer hair cells lack mechanotransduction currents
• however, tip-links appear to be intact
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behavior/neurological
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• reduced acceleration gain values at 2-3 months of age compared to wild-type controls but increased compared to double homozygous mice
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hearing/vestibular/ear
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• reduced acceleration gain values at 2-3 months of age compared to wild-type controls but increased compared to double homozygous mice
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hearing/vestibular/ear
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• significant reduction in transduction current amplitudes in outer hair cells from the P2-P4 basal cochlea
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nervous system
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• significant reduction in transduction current amplitudes in outer hair cells from the P2-P4 basal cochlea
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