Phenotypes associated with this allele

• Allele Symbol: Del(16Lipi-Usp25)1Dja
• Allele Name: deletion, Chr 16, David J Adams 1
• Allele ID: MGI:5427092
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(16Lipi-Usp25)1Dja/Del(16Lipi-Usp25)1Dja	involves: 129P2/OlaHsd * C57BL/6	MGI:5427095
ht2	Del(16Lipi-Usp25)1Dja/+	involves: 129P2/OlaHsd * C57BL/6	MGI:5427098

Genotype
MGI:5427095

hm1

• Allelic Composition: Del(16Lipi-Usp25)1Dja/Del(16Lipi-Usp25)1Dja
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size and increased apoptosis in Del(16Lipi-Usp25)1Dja/Del(16Lipi-Usp25)1Dja embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:184302 )

• mice die on or before E10.5

nervous system

increased neural tube apoptosis ( J:184302 )

• at E10.5, embryos exhibit increased apoptotic cells in the neural tube compared with wild-type mice

growth/size/body

decreased embryo size ( J:184302 )

• at E10.5

embryo

decreased embryo size ( J:184302 )

• at E10.5

cellular

increased neural tube apoptosis ( J:184302 )

• at E10.5, embryos exhibit increased apoptotic cells in the neural tube compared with wild-type mice

Genotype
MGI:5427098

ht2

• Allelic Composition: Del(16Lipi-Usp25)1Dja/+
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Del(16Lipi-Usp25)1Dja/+ mice show increased susceptibility to diet-induced obesity

growth/size/body

increased susceptibility to diet-induced obesity ( J:184302 )

• in mice fed a high-fat diet

adipose tissue

increased subcutaneous adipose tissue amount ( J:184302 )

• in mice fed a high-fat diet

increased total body fat amount ( J:184302 )

• in mice fed standard chow or a high-fat diet

increased percent body fat/body weight ( J:184302 )

behavior/neurological

abnormal social investigation ( J:184302 )

• in a 24 hour social memory retention test, mice are less capable of distinguishing between a familiar stimulus normal and an unfamiliar one compared than wild-type mice

liver/biliary system

hepatic steatosis ( J:184302 )

• more severe in mice fed a high-fat diet compared with similarly treated wild-type mice

integument

increased subcutaneous adipose tissue amount ( J:184302 )

• in mice fed a high-fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:184302 )

N • mice exhibit normal whole-body metabolism

increased susceptibility to diet-induced obesity ( J:184302 )

• in mice fed a high-fat diet

taste/olfaction

taste/olfaction phenotype ( J:184302 )

N • mice exhibit normal odor discrimination