All Phenotypes Pbx1<tm1.1Koss> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pbx1^tm1.1Koss
targeted mutation 1.1, Matthew J Koss
MGI:5426974

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nkx2-5^tm2(cre)Rph/Nkx2-5⁺ Pbx1^tm1.1Koss/Pbx1^tm1.1Koss	involves: 129P2/OlaHsd * 129S1/Sv	MGI:5426979
cn2	Pbx1^tm1.1Koss/Pbx1^tm1.1Koss Tg(WT1-cre)AG11Dbdr/0	involves: 129P2/OlaHsd * C57BL/6	MGI:5426981
cn3	Pbx1^tm1.1Koss/Pbx1^tm1.2Koss Tmem163^{Tg(ACTB-cre)2Mrt}/0	involves: 129P2/OlaHsd * FVB/N	MGI:5426978

Allelic Composition	Nkx2-5^tm2(cre)Rph/Nkx2-5⁺ Pbx1^tm1.1Koss/Pbx1^tm1.1Koss
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5^tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (21 available)
Pbx1^tm1.1Koss mutation (0 available); any Pbx1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal spleen morphology ( J:184521 )

• hypoplastic and fragmented

spleen hypoplasia ( J:184521 )

immune system

abnormal spleen morphology ( J:184521 )

• hypoplastic and fragmented

spleen hypoplasia ( J:184521 )

Allelic Composition	Pbx1^tm1.1Koss/Pbx1^tm1.1Koss Tg(WT1-cre)AG11Dbdr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1^tm1.1Koss mutation (0 available); any Pbx1 mutation (40 available)
Tg(WT1-cre)AG11Dbdr mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

spleen hypoplasia ( J:184521 )

immune system

spleen hypoplasia ( J:184521 )

Allelic Composition	Pbx1^tm1.1Koss/Pbx1^tm1.2Koss Tmem163^{Tg(ACTB-cre)2Mrt}/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1^tm1.1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx1^tm1.2Koss mutation (0 available); any Pbx1 mutation (40 available)
Tmem163^{Tg(ACTB-cre)2Mrt} mutation (3 available); any Tmem163 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent spleen ( J:184521 )

skeleton

abnormal humerus morphology ( J:184521 )

• phenotype duplicates that of global null mice

• fusion of the glenoid cavity of the scapula to the humeral head

• partial duplication of the head

abnormal deltoid tuberosity morphology ( J:184521 )

• detached

abnormal scapula morphology ( J:184521 )

• fusion of the glenoid cavity to the humeral head

scapular bone hypoplasia ( J:184521 )

• thin and hypoplastic

abnormal rib morphology ( J:184521 )

• phenotype duplicates that of global null mice

• truncated, dysmorphic, and occasionally fused ribs

rib fusion ( J:184521 )

• occasional

short ribs ( J:184521 )

• truncated

immune system

absent spleen ( J:184521 )

limbs/digits/tail

abnormal humerus morphology ( J:184521 )

• phenotype duplicates that of global null mice

• fusion of the glenoid cavity of the scapula to the humeral head

• partial duplication of the head

abnormal deltoid tuberosity morphology ( J:184521 )

• detached

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