All Phenotypes Ntf3<tm2.1Jae> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ntf3^tm2.1Jae
targeted mutation 2.1, Rudolf Jaenisch
MGI:5426960

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ntf3^tm2.1Jae/Ntf3^tm2Jae Olig2^tm2(cre)Htak/Olig2⁺	Not Specified	MGI:5426961

Allelic Composition	Ntf3^tm2.1Jae/Ntf3^tm2Jae Olig2^tm2(cre)Htak/Olig2⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3^tm2.1Jae mutation (0 available); any Ntf3 mutation (24 available)
Ntf3^tm2Jae mutation (1 available); any Ntf3 mutation (24 available)
Olig2^tm2(cre)Htak mutation (0 available); any Olig2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal sensory neuron innervation pattern ( J:182750 )

• axonal projections of Ia afferents do not reach the spinal cord in E15.5 homozygotes

abnormal dorsal root ganglion morphology ( J:182750 )

• cleaved Casp3-positive (apoptotic) neurons are significantly elevated in number in dorsal root ganglia at E10.5 compared to control embryos

abnormal proprioceptive neuron morphology ( J:182750 )

• number of TrkC- or Runx3-positive proprioceptive neurons is decreased in the DRGs at E13.5 compared to heterozygous controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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