Phenotypes associated with this allele

• Allele Symbol: Casp6^tm1.2Xen
• Allele Name: targeted mutation 1.2, Taconic Biosciences
• Allele ID: MGI:5426933
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp6^tm1.2Xen/Casp6^tm1.2Xen	FVB.B6NTac-Casp6^tm1.2Xen	MGI:5315761
ht2	Casp6^tm1.2Xen/Casp6^+	FVB.B6NTac-Casp6^tm1.2Xen	MGI:5315762

Genotype
MGI:5315761

hm1

• Allelic Composition: Casp6^tm1.2Xen/Casp6^tm1.2Xen
• Genetic Background: FVB.B6NTac-Casp6^tm1.2Xen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:181879 )

N • at 3 months, mice exhibit normal cortex volume, striatal volume, neuronal striatal counts, brain weight and cerebellum weight

N • at 8 months, mice exhibit normal brain and cerebellum weight

increased striatum size ( J:181879 )

• increased striatal volume at 8 months

abnormal cerebral cortex morphology ( J:181879 )

• increased cortical volume at 8 months

abnormal nervous system physiology ( J:181879 )

• after NFG withdrawal, neurons are protected from axonal degeneration compared with wild-type cells

• septal cholinergic neurons are protected from myelin-induced degeneration compared with wild-type cells

decreased susceptibility to neuronal excitotoxicity ( J:181879 )

• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells

behavior/neurological

abnormal response to novel object ( J:181879 )

• at 12 months, mice exhibit decreased novel object preference compared with wild-type mice

decreased locomotor activity ( J:181879 )

• in an open field

cellular

decreased susceptibility to neuronal excitotoxicity ( J:181879 )

• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:181879 )

• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells

Genotype
MGI:5315762

ht2

• Allelic Composition: Casp6^tm1.2Xen/Casp6⁺
• Genetic Background: FVB.B6NTac-Casp6^tm1.2Xen

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:181879 )

• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells

increased striatum size ( J:181879 )

• increased striatal volume at 8 months, not as much as in homozygotes

abnormal cerebral cortex morphology ( J:181879 )

• increased cortical volume at 8 months, not as much as in homozygotes

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:181879 )

• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells

cellular

decreased susceptibility to neuronal excitotoxicity ( J:181879 )

• medium spiny neurons are protected from NMDA-mediated excitotoxicity compared with wild-type cells