Phenotypes associated with this allele

• Allele Symbol: Phf14^tm1Take
• Allele Name: targeted mutation 1, Takumi Era
• Allele ID: MGI:5426539
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phf14^tm1Take/Phf14^tm1Take	B6.Cg-Phf14^tm1Take	MGI:5426686

Genotype
MGI:5426686

hm1

• Allelic Composition: Phf14^tm1Take/Phf14^tm1Take
• Genetic Background: B6.Cg-Phf14^tm1Take

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:184822 )

• embryos survive to E18.5 but pups die within 1 day after birth

respiratory system

abnormal pulmonary alveolus wall morphology ( J:184822 )

• hypertrophy of alveolar walls

• elevated cell density in lung tissue sections

• increased number of mesenchymal cells while numbers of epithelial cells, bronchial smooth muscle cells and vascular smooth muscle cells are normal

respiratory distress ( J:184822 )

• in neonates

respiratory failure ( J:184822 )

• resulting in death of neonates

homeostasis/metabolism

cyanosis ( J:184822 )

• in neonates

skeleton

abnormal sternum ossification ( J:184822 )

• ossification partially impaired

cellular

increased cell proliferation ( J:184822 )

• proliferation of bone marrow derived mesenchymal cells is increased

increased fibroblast proliferation ( J:184822 )

• MEFs grow faster in culture