Phenotypes associated with this allele

• Allele Symbol: Myl2^tm2.1Chen
• Allele Name: targeted mutation 2.1, Ju Chen
• Allele ID: MGI:5426525
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myl2^tm2.1Chen/Myl2^tm2.1Chen	B6.129-Myl2^tm2.1Chen	MGI:5426537

Genotype
MGI:5426537

hm1

• Allelic Composition: Myl2^tm2.1Chen/Myl2^tm2.1Chen
• Genetic Background: B6.129-Myl2^tm2.1Chen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dilated cardiomyopathy in Myl2^tm2.1Chen/Myl2^tm2.1Chen mice

mortality/aging

premature death ( J:184548 )

• associated with dilated cardiomyopathy and heart failure

cardiovascular system

increased myocardial fiber size ( J:184548 )

• increased length but not width at 6 months and 6 weeks, respectively

• following transverse aortic constriction

thin interventricular septum ( J:184548 )

• at 10 months

increased heart weight ( J:184548 )

• increased ventricle weight

increased heart left ventricle size ( J:184548 )

• increased left ventricular internal dimension at end diastole at 6 and 10 months

• increased left ventricular internal dimension at end systole at 2, 6 and 10 months

• following transverse aortic constriction at 6 weeks

dilated heart ventricle ( J:184548 )

cardiac fibrosis ( J:184548 )

• in some mice

dilated cardiomyopathy ( J:184548 )

dystrophic cardiac calcinosis ( J:184548 )

• in some mice

decreased ventricle muscle contractility ( J:184548 )

• decreased ejection fraction at 2, 6 and 10 months

• at 6 weeks following transverse aortic constriction

abnormal myocardial fiber physiology ( J:184548 )

• at 6 weeks, mice exhibit accelerated twitch compared to in wild-type mice

• however, intracellular calcium transients are normal

increased response of heart to induced stress ( J:184548 )

• following transverse aortic constriction, young mice exhibit increased left ventricle weight without a change in chamber wall thickness, reduced fractional shortening, increased left ventricular internal dimensions at diastole and systole, and increased cardiomyocyte length without a change in width compared with wild-type mice

congestive heart failure ( J:184548 )

homeostasis/metabolism

increased response of heart to induced stress ( J:184548 )

• following transverse aortic constriction, young mice exhibit increased left ventricle weight without a change in chamber wall thickness, reduced fractional shortening, increased left ventricular internal dimensions at diastole and systole, and increased cardiomyocyte length without a change in width compared with wild-type mice

muscle

increased myocardial fiber size ( J:184548 )

• increased length but not width at 6 months and 6 weeks, respectively

• following transverse aortic constriction

dilated cardiomyopathy ( J:184548 )

decreased ventricle muscle contractility ( J:184548 )

• decreased ejection fraction at 2, 6 and 10 months

• at 6 weeks following transverse aortic constriction

abnormal Z line morphology ( J:184548 )

• thickened at 6 months

growth/size/body

increased heart weight ( J:184548 )

• increased ventricle weight