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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arg1tm1Ekoe
targeted mutation 1, Eleonore Kohler
MGI:5426515
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arg1tm1Ekoe/Arg1tm1Ekoe involves: 129P2/OlaHsd MGI:5426520


Genotype
MGI:5426520
hm1
Allelic
Composition		 Arg1tm1Ekoe/Arg1tm1Ekoe
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arg1tm1Ekoe mutation (1 available); any Arg1 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:183882 )
• IL4-stimulated macrophage are unable of depleting culture medium of arginine and do not secrete ornithine unlike control cells

homeostasis/metabolism
abnormal blood homeostasis ( J:183882 )
• mice exhibit elevated polyamine levels compared with wild-type mice

hematopoietic system
abnormal macrophage physiology ( J:183882 )
• IL4-stimulated macrophage are unable of depleting culture medium of arginine and do not secrete ornithine unlike control cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory