Analysis Tools
homeostasis/metabolism
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• induction of antibody-induced glomerulonephritis by immunizing mutants with rabbit IgG followed by rabbit nephrotoxic serum results in more severe glomerular injury than in wild-type mice; mutants exhibit increased extracapillary proliferation and glomerular deposition of PAS-positive material
• mutants exhibit a 5-fold higher level of proteinuria following antibody-induced glomerulonephritis than wild-type mice, indicating that mutants exhibit increased susceptibility to immune-mediated tissue injury
• treatment with anti-IL-17 of mice with induced glomerulonephritis decreases the amount of proteinuria and extent of histological damage
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immune system
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• mutants show a mild increase in the size of the spleen, however architecture is normal
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• neutrophil counts are increased in the peripheral blood
• increase in neutrophil generation as indicated by a significantly higher percentage of bone marrow cells that are Gr+CD11b+ than in wild-type mice
• mutants exhibit increased neutrophil infiltration in the kidneys following antibody-induced glomerulonephritis compared to wild-type mice
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• mutants exhibit a modest increase in the number of germinal center B cells in mesenteric lymph nodes
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• mutants exhibit a slight increase in the CD4/CD8 T cell ratio
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• mutants show a mild increase in the size of the lymph nodes, however architecture is normal
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• naive CD4 T cells stimulated with anti-CD3 or CD28 antibodies produce 9-fold higher levels of IL-17a than stimulated wild-type T cells
• spontaneous production of IL-17 by lymph node cells is more common in mutants than wild-type
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• while mutants do not develop spontaneous disease, mutants exhibit increased susceptibility to antibody-induced glomerulonephritis compared to controls
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hematopoietic system
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• mutants show a mild increase in the size of the spleen, however architecture is normal
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• neutrophil counts are increased in the peripheral blood
• increase in neutrophil generation as indicated by a significantly higher percentage of bone marrow cells that are Gr+CD11b+ than in wild-type mice
• mutants exhibit increased neutrophil infiltration in the kidneys following antibody-induced glomerulonephritis compared to wild-type mice
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• mutants exhibit a modest increase in the number of germinal center B cells in mesenteric lymph nodes
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• mutants exhibit a slight increase in the CD4/CD8 T cell ratio
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renal/urinary system
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• while mutants do not develop spontaneous disease, mutants exhibit increased susceptibility to antibody-induced glomerulonephritis compared to controls
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growth/size/body
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• mutants show a mild increase in the size of the spleen, however architecture is normal
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