Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm2Llm mutation
(0 available);
any
Fgfr3 mutation
(52 available)
Tg(Col1a1-cre)1Kry mutation
(2 available)
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|
|
skeleton
N |
• no obvious skeletal phenotype
• normal growth plates
• primary spongiosa is normal
• normal trabecular bone
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm2Llm mutation
(0 available);
any
Fgfr3 mutation
(52 available)
Tg(CMV-cre)1Ipc mutation
(0 available)
|
|
|
growth/size/body
skeleton
|
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased
|
|
• fewer subchondral trabeculae
• trabeculae only partially mineralized
• more abundant collagen deposition
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur
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• smaller hypertrophic mineralization zone
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• reduced size of epiphysis
|
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• defect in mineralization of calcified cartilage and primary spongiosa
|
craniofacial
hematopoietic system
|
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased
|
immune system
|
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm2Llm mutation
(0 available);
any
Fgfr3 mutation
(52 available)
Tg(Col2a1-cre)1Bhr mutation
(3 available)
|
|
|
growth/size/body
skeleton
|
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased
|
|
• fewer subchondral trabeculae
• trabeculae only partially mineralized
• more abundant collagen deposition
• significantly lower bone volume/trabecular volume in distal metaphysis of the femur
|
|
• smaller hypertrophic mineralization zone
|
|
• lack proliferative column organization
• proliferative zone reduced
|
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• reduced hypertrophic zone
• small hypertrophic cells
|
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• reduced size of epiphysis
|
|
• defect in mineralization of calcified cartilage and primary spongiosa
|
|
• delayed formation of secondary ossification centers
|
craniofacial
hematopoietic system
|
• osteoclasts per bone area are increased
• osteoclast surface area/bone surface area is increased
|
immune system
|
• osteoclast surface area/bone surface area is increased
• osteoclasts per bone area are increased
|