Phenotypes associated with this allele

• Allele Symbol: Nlrc5^tm1.1Ggaur
• Allele Name: targeted mutation 1.1, Greta Guarda
• Allele ID: MGI:5426421
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrc5^tm1.1Ggaur/Nlrc5^tm1.1Ggaur	involves: BALB/cJ	MGI:5426424

Genotype
MGI:5426424

hm1

• Allelic Composition: Nlrc5^tm1.1Ggaur/Nlrc5^tm1.1Ggaur
• Genetic Background: involves: BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:184076 )

N • bone marrow-derived macrophage cells exhibit normal stimulation of OT-I T cells

enlarged spleen ( J:184076 )

• at 34 to 36 weeks

decreased CD8-positive, alpha-beta T cell number ( J:184076 )

• slight decrease in percentage in spleen, lymph nodes and blood

abnormal T cell physiology ( J:184076 )

• T cells pulsed with SIINFEKL peptide and incubated with OT-I CD8+ effector T cells are less effectively killed by OT-I T cells compared with control cells

hematopoietic system

enlarged spleen ( J:184076 )

• at 34 to 36 weeks

decreased CD8-positive, alpha-beta T cell number ( J:184076 )

• slight decrease in percentage in spleen, lymph nodes and blood

abnormal T cell physiology ( J:184076 )

• T cells pulsed with SIINFEKL peptide and incubated with OT-I CD8+ effector T cells are less effectively killed by OT-I T cells compared with control cells

growth/size/body

enlarged spleen ( J:184076 )

• at 34 to 36 weeks