Phenotypes associated with this allele

• Allele Symbol: Hes7^tm3.1Dihz
• Allele Name: targeted mutation 3.1, David Ish-Horowicz
• Allele ID: MGI:5426215
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hes7^tm3.1Dihz/Hes7^tm3.1Dihz	involves: 129 * C57BL/6J	MGI:5426224
ht2	Hes7^tm3.1Dihz/Hes7^+	involves: 129 * C57BL/6J	MGI:5426223

Genotype
MGI:5426224

hm1

• Allelic Composition: Hes7^tm3.1Dihz/Hes7^tm3.1Dihz
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:184024 )

• mice die between birth and weaning

skeleton

abnormal skeleton morphology ( J:184024 )

abnormal rib morphology ( J:184024 )

• extensive and severe malformations at E18.5

rib fusion ( J:184024 )

• at E18.5

abnormal vertebrae morphology ( J:184024 )

• extensive and severe malformations at E18.5

abnormal sacral vertebrae morphology ( J:184024 )

• at E18.5

vertebral fusion ( J:184024 )

• at E18.5

embryo

abnormal somite development ( J:184024 )

• mice exhibit disorganized expression of the segmentation marker Uncx4.1

limbs/digits/tail

short tail ( J:184024 )

• at E18.5

Genotype
MGI:5426223

ht2

• Allelic Composition: Hes7^tm3.1Dihz/Hes7⁺
• Genetic Background: involves: 129 * C57BL/6J

limbs/digits/tail

kinked tail ( J:184024 )

• in few mice