Phenotypes associated with this allele

• Allele Symbol: Hes7^tm2.1Dihz
• Allele Name: targeted mutation 2.1, David Ish-Horowicz
• Allele ID: MGI:5426214
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hes7^tm2.1Dihz/Hes7^tm2.1Dihz	involves: 129 * C57BL/6J	MGI:5426219
ht2	Hes7^tm2.1Dihz/Hes7^+	involves: 129 * C57BL/6J	MGI:5426218
ht3	Hes7^tm1Kag/Hes7^tm2.1Dihz	involves: 129 * C57BL/6J	MGI:5426222

Genotype
MGI:5426219

hm1

• Allelic Composition: Hes7^tm2.1Dihz/Hes7^tm2.1Dihz
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:184024 )

• mice die between birth and weaning

skeleton

abnormal skeleton morphology ( J:184024 )

• disorganized at E18.5

abnormal rib morphology ( J:184024 )

• extensive and severe malformations

rib fusion ( J:184024 )

• at E18.5

abnormal vertebral column morphology ( J:184024 )

• at E18.5, mice lack regular vertebrae

limbs/digits/tail

short tail ( J:184024 )

• truncated at E18.5

Genotype
MGI:5426218

ht2

• Allelic Composition: Hes7^tm2.1Dihz/Hes7⁺
• Genetic Background: involves: 129 * C57BL/6J

limbs/digits/tail

kinked tail ( J:184024 )

• in few mice

Genotype
MGI:5426222

ht3

• Allelic Composition: Hes7^tm1Kag/Hes7^tm2.1Dihz
• Genetic Background: involves: 129 * C57BL/6J

skeleton

abnormal skeleton morphology ( J:184024 )

• disorganized at E18.5

abnormal rib morphology ( J:184024 )

• extensive and severe malformations at E18.5

rib fusion ( J:184024 )

• at E18.5

abnormal vertebral column morphology ( J:184024 )

• at E18.5, mice lack regular vertebrae

abnormal vertebrae morphology ( J:184024 )

• extensive and severe malformations at E18.5

abnormal sacral vertebrae morphology ( J:184024 )

• at E18.5

vertebral fusion ( J:184024 )

• at E18.5

limbs/digits/tail

short tail ( J:184024 )

• at E18.5