Phenotypes associated with this allele

• Allele Symbol: Mstn^tm1.1Mgs
• Allele Name: targeted mutation 1.1, Michel Georges
• Allele ID: MGI:5425956
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mstn^tm1.1Mgs/Mstn^tm1.1Mgs	involves: 129S1/Sv * 129X1/SvJ * C57BL * FVB/N	MGI:5425957

Genotype
MGI:5425957

hm1

• Allelic Composition: Mstn^tm1.1Mgs/Mstn^tm1.1Mgs
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:184622 )

• skeletal muscles exhibit mitochondria depletion compared with wild-type muscles

increased skeletal muscle weight ( J:184622 )

skeletal muscle hypertrophy ( J:184622 )

• 221%, 187% and 132% for extensor digitorum longus, gastrocnemius and soleus

abnormal muscle physiology ( J:184622 )

• skeletal muscles exhibit reduced redox basal state compared with wild-type cells

• antioxidant SOD and catalase activities are reduced compared to in wild-type cells

• skeletal muscles exhibit impaired specific force and fiber tolerance to chronic repetitive contraction compared with wild-type cells

• however, reactive oxygen species production is normal

cellular

oxidative stress ( J:184622 )

• antioxidant SOD and catalase activities are reduced compared to in wild-type cells

• however, reactive oxygen species production is normal

growth/size/body

increased body weight ( J:184622 )

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:184622 )

• skeletal muscles exhibit increased COX activity compared with wild-type cells