All Phenotypes Gli3<tm1.2Zllr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gli3^tm1.2Zllr
targeted mutation 1.2, Rolf Zeller
MGI:5425256

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli3^tm1.2Zllr/Gli3^tm1.2Zllr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5523595
ht2	Gli3^tm1.2Zllr/Gli3^Xt-J	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J * NMRI	MGI:5425260
cn3	Gli3^tm1.1Zllr/Gli3^tm1.2Zllr Hoxa13^{tm1.1(cre)Makm}/Hoxa13⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5425261
cx4	Gli3^tm1.2Zllr/Gli3^tm1.2Zllr Pkdcc^tm1.2Azun/Pkdcc^tm1.2Azun	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5523593
cx5	Gli3^tm1.2Zllr/Gli3⁺ Pkdcc^tm1.2Azun/Pkdcc^tm1.2Azun	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5523594

Allelic Composition	Gli3^tm1.2Zllr/Gli3^tm1.2Zllr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm1.2Zllr mutation (0 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

absent tibia ( J:199462 )

abnormal endochondral bone ossification ( J:199462 )

• ossification centers in the limb bones are smaller at E16.5

limbs/digits/tail

polydactyly ( J:199462 )

absent tibia ( J:199462 )

hemimelia ( J:199462 )

• of the tibia

Allelic Composition	Gli3^tm1.2Zllr/Gli3^Xt-J
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm1.2Zllr mutation (0 available); any Gli3 mutation (80 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:184012 )

• additional anterior digits are formed but the anterior most digit 1 is lost

nervous system

abnormal brain morphology ( J:184012 )

• brain abnormalities similar to mice homozygous for Gli3^Xt-J

vision/eye

abnormal eye morphology ( J:184012 )

• eye abnormalities similar to mice homozygous for Gli3^Xt-J

Allelic Composition	Gli3^tm1.1Zllr/Gli3^tm1.2Zllr Hoxa13^{tm1.1(cre)Makm}/Hoxa13⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm1.1Zllr mutation (0 available); any Gli3 mutation (80 available)
Gli3^tm1.2Zllr mutation (0 available); any Gli3 mutation (80 available)
Hoxa13^{tm1.1(cre)Makm} mutation (0 available); any Hoxa13 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:184012 )

Allelic Composition	Gli3^tm1.2Zllr/Gli3^tm1.2Zllr Pkdcc^tm1.2Azun/Pkdcc^tm1.2Azun
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm1.2Zllr mutation (0 available); any Gli3 mutation (80 available)
Pkdcc^tm1.2Azun mutation (0 available); any Pkdcc mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

absent fibula ( J:199462 )

• the primordia of the tibia and fibula are ectromelic at E16.5

absent tibia ( J:199462 )

• the primordia of the tibia and fibula are ectromelic at E16.5

abnormal scapula morphology ( J:199462 )

• deformed in some mice at E16.5

abnormal cartilage development ( J:199462 )

• at E16.5 few or no columnar and hypertrophic chondrocytes are detected in the limbs

• hypertrophic differentiation is delayed

• expression analysis indicates the number of pre-hypertrophic chondrocytes is severely reduced in the limbs at E15.5 and E16.5

delayed endochondral bone ossification ( J:199462 )

• at E16.5 no signs of ossification are seen in the humerus, tibia, fibula or digits and mineralization domains in other long bones are reduced

• delay is more severe than in mice homozygous for Pkdcc^tm1.2Azun alone

limbs/digits/tail

polydactyly ( J:199462 )

absent fibula ( J:199462 )

• the primordia of the tibia and fibula are ectromelic at E16.5

absent tibia ( J:199462 )

• the primordia of the tibia and fibula are ectromelic at E16.5

Allelic Composition	Gli3^tm1.2Zllr/Gli3⁺ Pkdcc^tm1.2Azun/Pkdcc^tm1.2Azun
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased length of long bones ( J:199462 )

• shorter ossified section at birth

• more severe than in mice homozygous for the Pkdcc mutation alone

short humerus ( J:199462 )

• tibia and humerus are most severely affected

short tibia ( J:199462 )

• tibia and humerus are most severely affected

abnormal scapula morphology ( J:199462 )

• deformed in some mice at E16.5

delayed endochondral bone ossification ( J:199462 )

• in long bones

• more severe than in mice homozygous for the Pkdcc mutation alone

limbs/digits/tail

short humerus ( J:199462 )

• tibia and humerus are most severely affected

short tibia ( J:199462 )

• tibia and humerus are most severely affected

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