All Phenotypes Tph2<tm1Mscl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tph2^tm1Mscl
targeted mutation 1, Michael S Clark
MGI:5318587

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Tph2^tm1Mscl/Tph2^tm1Mscl	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr	MGI:5427450

Allelic Composition	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Tph2^tm1Mscl/Tph2^tm1Mscl
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^{tm2(HBEGF)Rpa} mutation (1 available); any Agrp mutation (18 available)
Tph2^tm1Mscl mutation (0 available); any Tph2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal eating behavior ( J:182577 )

• in diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries

growth/size/body

abnormal postnatal growth/weight/body size ( J:182577 )

• diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries prevents starvation induced by AgRP neuron ablation unlike in control mice

homeostasis/metabolism

decreased serotonin level ( J:182577 )

• in diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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