All Phenotypes Tph2<tm1Mscl> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tph2^tm1Mscl
targeted mutation 1, Michael S Clark
MGI:5318587

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Tph2^tm1Mscl/Tph2^tm1Mscl	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr	MGI:5427450

Allelic Composition	Agrp^{tm2(HBEGF)Rpa}/Agrp⁺ Tph2^tm1Mscl/Tph2^tm1Mscl
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^{tm2(HBEGF)Rpa} mutation (1 available); any Agrp mutation (20 available)
Tph2^tm1Mscl mutation (0 available); any Tph2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal eating behavior ( J:182577 )

• in diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries

growth/size/body

abnormal postnatal growth/weight/body size ( J:182577 )

• diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries prevents starvation induced by AgRP neuron ablation unlike in control mice

homeostasis/metabolism

decreased serotonin level ( J:182577 )

• in diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24