Phenotypes associated with this allele

• Allele Symbol: Klf10^tm1Wkle
• Allele Name: targeted mutation 1, Woon Kyu Lee
• Allele ID: MGI:5317944
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf10^tm1Wkle/Klf10^tm1Wkle	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5317947

Genotype
MGI:5317947

hm1

• Allelic Composition: Klf10^tm1Wkle/Klf10^tm1Wkle
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:182595 )

• mice treated with DMBA and TPA exhibit increased formation and growth of papillomas compared with wild-type mice

increased tumor growth/size ( J:182595 )

• mice treated with DMBA and TPA exhibit increased formation and growth of papillomas compared with wild-type mice

increased papilloma incidence ( J:182595 )

• mice treated with DMBA and TPA exhibit increased formation and growth of papillomas compared with wild-type mice

decreased tumor latency ( J:182595 )

• all mice treated with DMBA and TPA develop tumors 7 weeks post-treatment compared with 15 weeks for all wild-type mice to develop tumors

integument

increased keratinocyte apoptosis ( J:182595 )

• following treatment with DMBA and TPA

increased keratinocyte proliferation ( J:182595 )

• following treatment with DMBA and TPA

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:182595 )

• mice treated with DMBA and TPA exhibit increased formation and growth of papillomas compared with wild-type mice

cellular

increased keratinocyte apoptosis ( J:182595 )

• following treatment with DMBA and TPA

increased keratinocyte proliferation ( J:182595 )

• following treatment with DMBA and TPA