Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Mir21,-EGFP)#Eno
• Allele Name: transgene insertion, Eric N Olson
• Allele ID: MGI:5317720
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Kras^tm3Tyj/Kras^+ Tg(CAG-Mir21,-EGFP)#Eno/0	involves: 129S4/SvJae * C3H * C57BL/6	MGI:5317786
tg2	Tg(CAG-Mir21,-EGFP)#Eno/0	involves: C3H * C57BL/6	MGI:5317785

Genotype
MGI:5317786

cx1

• Allelic Composition: Kras^tm3Tyj/Kras⁺; Tg(CAG-Mir21,-EGFP)#Eno/0
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:164198 )

• mice exhibit premature death compared with wild-type mice

• however, mice exhibit the same mortality as Kras^tm3Tyj heterozygotes

neoplasm

increased tumor growth/size ( J:164198 )

• increased proliferation of tumor cells compared with tumor cells from Kras^tm3Tyj heterozygotes

increased lung tumor incidence ( J:164198 )

• at 18 weeks compared with Kras^tm3Tyj heterozygotes

• mice develop increased incidence of all tumor grades without increasing the rate of conversion to adenocarcinoma compared with Kras^tm3Tyj heterozygotes

increased lung non-small cell carcinoma incidence ( J:164198 )

decreased tumor incidence ( J:164198 )

• of thymic tumors compared with Kras^tm3Tyj heterozygotes

respiratory system

increased lung tumor incidence ( J:164198 )

• at 18 weeks compared with Kras^tm3Tyj heterozygotes

• mice develop increased incidence of all tumor grades without increasing the rate of conversion to adenocarcinoma compared with Kras^tm3Tyj heterozygotes

increased lung non-small cell carcinoma incidence ( J:164198 )

Genotype
MGI:5317785

tg2

• Allelic Composition: Tg(CAG-Mir21,-EGFP)#Eno/0
• Genetic Background: involves: C3H * C57BL/6

neoplasm

neoplasm ( J:164198 )

N • mice do not develop tumors