Phenotypes associated with this allele

• Allele Symbol: Mir22^tm1.1Arod
• Allele Name: targeted mutation 1.1, Antony Rodriguez
• Allele ID: MGI:5317341
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir22^tm1.1Arod/Mir22^tm1.1Arod	involves: 129S1/SvImJ * 129S7/SvEvBrd	MGI:5317342

Genotype
MGI:5317342

hm1

• Allelic Composition: Mir22^tm1.1Arod/Mir22^tm1.1Arod
• Genetic Background: involves: 129S1/SvImJ * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:183005 )

N • mice exhibit no cardiac pathology under basal conditions

dilated heart ventricle ( J:183005 )

• after transverse aortic constriction

cardiac fibrosis ( J:183005 )

• after transverse aortic constriction

abnormal cardiovascular system physiology ( J:183005 )

• mice treated with dobutamine exhibit impaired contractile reserve and intracellular calcium homeostasis compared with wild-type mice

decreased cardiac muscle contractility ( J:183005 )

• after transverse aortic constriction

• mice treated with dobutamine exhibit impaired contractile reserve and intracellular calcium homeostasis compared with wild-type mice

congestive heart failure ( J:183005 )

• after transverse aortic constriction

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:183005 )

• mice treated with dobutamine exhibit impaired contractile reserve and intracellular calcium homeostasis compared with wild-type mice

muscle

decreased cardiac muscle contractility ( J:183005 )

• after transverse aortic constriction

• mice treated with dobutamine exhibit impaired contractile reserve and intracellular calcium homeostasis compared with wild-type mice