Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitftm3.1Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
Tg(PAX6)77Ndha mutation
(0 available)
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vision/eye
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N |
• no dorsal thickening of the retinal pigment epithelium observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6Sey mutation
(9 available);
any
Pax6 mutation
(90 available)
Tg(PAX6)77Ndha mutation
(0 available)
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vision/eye
taste/olfaction
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N |
• nasal cavity present
• normal olfactory epithelium
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nervous system
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N |
• olfactory bulbs normal
• subventricular zone of cerebral hemispheres normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation
(1 available);
any
Mitf mutation
(72 available)
Tg(PAX6)77Ndha mutation
(0 available)
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vision/eye
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N |
• no thickening of the retinal pigment epithelium
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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vision/eye
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N |
• no thickening of the retinal pigment epithelium
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• lens defects do not appear until after E12.5
• retinal attachment to the lens develops as the vitreous disappears
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• eyes are significantly smaller by E14.5
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• fewer retinal ganglion cell axons reach the optic chiasma
• reduction in contralateral projection of retinal ganglion cell axons
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• retinal attachment to the lens develops as the vitreous disappears
• rosette-like structures in the retina at 4 days of age
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• extends along the optic stalk
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• extends along the optic stalk
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• less structured at E18.5
• retinal ganglion cell axons follow a more erratic course toward the optic nerve
• fewer retinal ganglion cell axons reach the optic chiasma
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• peripheral retina folds back toward the vitreous chamber
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• vitreous chamber almost completely disappears by 2 days of age
• hyperplastic vitreous at E14.5
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pigmentation
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• extends along the optic stalk
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nervous system
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• fewer retinal ganglion cell axons reach the optic chiasma
• reduction in contralateral projection of retinal ganglion cell axons
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Allelic
Composition |
Tg(PAX6)77Ndha/?
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Genetic
Background |
involves: C57BL/6 * CBA |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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vision/eye
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• disorganized in normal sized eyes
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• cyst-like structures in the iris of normal sized eyes
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• retinal attachments to the lens
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• high percentage of mice with reduced eye size
• microphthalmic eyes highly disorganized
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• retinal attachments to the lens
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Analysis Tools
