All Phenotypes Yap1<tm2.1Fcam> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Yap1^tm2.1Fcam
targeted mutation 2.1, Fernando D Camargo
MGI:5316452

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Yap1^tm1.1Fcam/Yap1^tm2.1Fcam Tg(KRT14-cre)1Amc/0	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:5316467

Allelic Composition	Yap1^tm1.1Fcam/Yap1^tm2.1Fcam Tg(KRT14-cre)1Amc/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Amc mutation (2 available)
Yap1^tm1.1Fcam mutation (0 available); any Yap1 mutation (37 available)
Yap1^tm2.1Fcam mutation (0 available); any Yap1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:171057 )

integument

abnormal skin morphology ( J:171057 )

• authors state that mice phenocopy Yap1^tm1.1Fcam/Yap1^tm1.1Fcam Tg(KRT14-cre)1Amc mice

abnormal epidermal layer morphology ( J:171057 )

• at E18.5, mice lack epidermal tissue covering the distal part of the limbs, eyes and ears

thin skin ( J:171057 )

• limb skin

cellular

decreased cell proliferation ( J:171057 )

• mice exhibit reduced proliferation of basal cells in limb skin compared with control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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