Phenotypes associated with this allele

• Allele Symbol: Cfl2^tm1.1Itl
• Allele Name: targeted mutation 1.1, inGenious Targeting Laboratory
• Allele ID: MGI:5316057
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cfl2^tm1.1Itl/Cfl2^tm1.1Itl	involves: C57BL/6J * C57BL/6NTac	MGI:5316092

Genotype
MGI:5316092

hm1

• Allelic Composition: Cfl2^tm1.1Itl/Cfl2^tm1.1Itl
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:182571 )

• none survive past P8

muscle

abnormal sarcomere morphology ( J:182571 )

• skeletal muscle myofibers lack well-defined A- and I- bands with areas of normal-looking sarcomeres unlike in wild-type mice

abnormal skeletal muscle morphology ( J:182571 )

• accumulation of F-actin

abnormal skeletal muscle fiber morphology ( J:182571 )

• skeletal muscle myofibers lack well-defined A- and I- bands with areas of normal-looking sarcomeres unlike in wild-type mice

• skeletal muscle myofibers accumulate abnormal mitochondria unlike in wild-type mice

skeletal muscle fiber degeneration ( J:182571 )

• occasionally at P3

• extensive and severe at P7

• at P7, mice exhibit ballooning degeneration interspersed with normal-looking myofibers and pale core-like areas consistent with myofibrillar disruption and absent mitochondria unlike in wild-type mice

abnormal skeletal muscle fiber type ratio ( J:182571 )

• increase in the mean percentage of slow fibers

muscle weakness ( J:182571 )

• mice exhibit muscle weakness

• however, mice exhibit normal neuromuscular junctions and nerve myelination

growth/size/body

decreased body size ( J:182571 )

• by P7

decreased body weight ( J:182571 )

• by P7

decreased body length ( J:182571 )

postnatal growth retardation ( J:182571 )

• from P3 and P7

behavior/neurological

abnormal food intake ( J:182571 )

• little to no mild in the stomach suggests inability to suckle by P7

abnormal suckling behavior ( J:182571 )

• little to no mild in the stomach suggests inability to suckle by P7

impaired righting response ( J:182571 )

abnormal locomotor activation ( J:182571 )

• reduced spontaneous activity

nervous system

nervous system phenotype ( J:182571 )

N • mice exhibit normal neuromuscular junctions and nerve myelination