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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Huwe1tm1Wgu
targeted mutation 1, Wei Gu
MGI:5315772
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Huwe1tm1Wgu/Huwe1tm1Wgu involves: C57BL/6J MGI:5315849
cn2
 		Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0 		involves: C57BL/6J * CBA/J MGI:5315852
cn3
 		Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
Trp53tm1Thl/Trp53tm1Thl 		involves: C57BL/6J * CBA/J MGI:5315853
ot4
 		Huwe1tm1Wgu/Y involves: C57BL/6J MGI:5315850


Genotype
MGI:5315849
hm1
Allelic
Composition		 Huwe1tm1Wgu/Huwe1tm1Wgu
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Huwe1tm1Wgu mutation (0 available); any Huwe1 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:182446 )
• mice are grossly normal and fertile




Genotype
MGI:5315852
cn2
Allelic
Composition		 Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Huwe1tm1Wgu mutation (0 available); any Huwe1 mutation (63 available)
Tg(Ins2-cre)23Herr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Loss of pancreatic beta-cells in aged Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr/0 mice

mortality/aging
premature death ( J:182446 )
• more than half mice died at less than 1 year of age due to severe diabetic symptoms

homeostasis/metabolism
increased circulating glucose level ( J:182446 )
• in fasting and fed mice at 6 and 9 months of age
hyperglycemia ( J:182446 )
• progressive
decreased circulating insulin level ( J:182446 )
• in fasting mice at 9 months
• in fed mice at 6 and 9 months
impaired glucose tolerance ( J:182446 )
• at 3 and 6 months

endocrine/exocrine glands
decreased pancreatic beta cell number ( J:182446 )
• at 6 months and worsening at 9 months
disorganized pancreatic islets ( J:182446 )
• at 6 months and worsening at 9 months, mice exhibit infiltration of alpha cells into the middle of islets unlike in wild-type mice

renal/urinary system

growth/size/body
decreased body weight ( J:182446 )
• at 9 months




Genotype
MGI:5315853
cn3
Allelic
Composition		 Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
Trp53tm1Thl/Trp53tm1Thl
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Huwe1tm1Wgu mutation (0 available); any Huwe1 mutation (63 available)
Tg(Ins2-cre)23Herr mutation (1 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:182446 )
N
• mice survive longer than Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:182446 )
N
• diabetic symptoms (serum glucose and insulin levels and glucose intolerance) observed in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice are improved
hyperglycemia ( J:182446 )
• in fasting mice at 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice
• in fed mice at 3, 6 and 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:182446 )
N
• islet organization is improved compared to in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice




Genotype
MGI:5315850
ot4
Allelic
Composition		 Huwe1tm1Wgu/Y
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Huwe1tm1Wgu mutation (0 available); any Huwe1 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:182446 )
• mice are grossly normal and fertile




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory