Phenotypes associated with this allele

• Allele Symbol: Prdm8^tm1Mci
• Allele Name: targeted mutation 1, Roderick R McInnes
• Allele ID: MGI:5315763
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prdm8^tm1Mci/Prdm8^tm1Mci	involves: 129S6/SvEvTac * C57BL/6J	MGI:5315764

Genotype
MGI:5315764

hm1

• Allelic Composition: Prdm8^tm1Mci/Prdm8^tm1Mci
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:182304 )

N • mice exhibit normal cortical layering

abnormal motor neuron axon guidance ( J:182304 )

• in most mice, axons from corticospinal motor neurons terminal prematurely and fail to enter the spinal cord unlike in wild-type mice

absent corpus callosum ( J:182304 )

• in most mice

absent hippocampal commissure ( J:182304 )

• in most mice

behavior/neurological

excessive scratching ( J:182304 )

• resulting in skin lesions in most mice at 6 weeks of age

abnormal motor coordination/balance ( J:182304 )

• a few mice exhibit a handstand phenotype (walking on forepaws) secondary to hindpaw contraction

integument

skin lesions ( J:182304 )

• due to excessive scratching in most mice at 6 weeks of age

cellular

abnormal motor neuron axon guidance ( J:182304 )

• in most mice, axons from corticospinal motor neurons terminal prematurely and fail to enter the spinal cord unlike in wild-type mice