Phenotypes associated with this allele

• Allele Symbol: Arl6ip5^tm1Tnkk
• Allele Name: targeted mutation 1, Toshio Nakaki
• Allele ID: MGI:5315599
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arl6ip5^tm1Tnkk/Arl6ip5^tm1Tnkk	either: B6.Cg-Arl6ip5^tm1Tnkk or (involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj)	MGI:5315708
ht2	Arl6ip5^tm1Tnkk/Arl6ip5^+	either: B6.Cg-Arl6ip5^tm1Tnkk or (involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj)	MGI:5315709

Genotype
MGI:5315708

hm1

• Allelic Composition: Arl6ip5^tm1Tnkk/Arl6ip5^tm1Tnkk
• Genetic Background: either: B6.Cg-Arl6ip5^tm1Tnkk or (involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:182338 )

N • at 5 months, mice exhibit normal clasping

abnormal motor learning ( J:182338 )

• improved in a rotarod test

abnormal spatial working memory ( J:182338 )

• in a Morris water maze test, mice exhibit decreased latency to finding a hidden platform on days 3 through 5 compared with wild-type mice

• however, latency to finding a visible platform is normal

enhanced coordination ( J:182338 )

• in a rotarod test

decreased locomotor activity ( J:182338 )

• with respect to exploratory measures in an open field test

cellular

abnormal redox activity ( J:182338 )

• brain slices incubated with 3-morpholinosydnonimine (SIN-1) exhibit increased resistance to oxidative stress compared with wild-type slices

growth/size/body

decreased body weight ( J:182338 )

• at 5 months

nervous system

nervous system phenotype ( J:182338 )

N • at 5 months, mice exhibit normal brain morphology

Genotype
MGI:5315709

ht2

• Allelic Composition: Arl6ip5^tm1Tnkk/Arl6ip5⁺
• Genetic Background: either: B6.Cg-Arl6ip5^tm1Tnkk or (involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj)

behavior/neurological

decreased locomotor activity ( J:182338 )

• with respect to exploratory measures in an open field test