Phenotypes associated with this allele

• Allele Symbol: Ror2^tm1.2Meg
• Allele Name: targeted mutation 1.2, Michael E Greenberg
• Allele ID: MGI:5315486
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ror2^tm1.2Meg/Ror2^tm1.2Meg	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5315488
cx2	Ror1^tm1.2Meg/Ror1^tm1.2Meg Ror2^tm1.2Meg/Ror2^tm1.2Meg	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5315489

Genotype
MGI:5315488

hm1

• Allelic Composition: Ror2^tm1.2Meg/Ror2^tm1.2Meg
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Morphogenesis defects in Ror2^tm1.2Meg/Ror2^tm1.2Meg mice

craniofacial

abnormal facial morphology ( J:182150 )

• facial malformations

limbs/digits/tail

short limbs ( J:182150 )

• truncation of the limbs

embryo

caudal body truncation ( J:182150 )

growth/size/body

abnormal facial morphology ( J:182150 )

• facial malformations

Genotype
MGI:5315489

cx2

• Allelic Composition: Ror1^tm1.2Meg/Ror1^tm1.2Meg; Ror2^tm1.2Meg/Ror2^tm1.2Meg
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Ror1^tm1.2Meg/Ror1^tm1.2Meg Ror2^tm1.2Meg/Ror2^tm1.2Meg embryos exhibit morphogenesis defects

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:182150 )

• do not survive to term and most die by E15.5

craniofacial

abnormal facial morphology ( J:182150 )

• more severe facial malformations than in Ror2^tm1.2Meg single homozygotes

limbs/digits/tail

short limbs ( J:182150 )

• more severe truncation of the limbs than in Ror2^tm1.2Meg single homozygotes

embryo

caudal body truncation ( J:182150 )

• more severe than in Ror2^tm1.2Meg single homozygotes

homeostasis/metabolism

hydrops fetalis ( J:182150 )

• edema in the trunk

nervous system

exencephaly ( J:182150 )

• occasional

growth/size/body

abnormal facial morphology ( J:182150 )

• more severe facial malformations than in Ror2^tm1.2Meg single homozygotes