Analysis Tools
hearing/vestibular/ear
| N |
• Background Sensitivity: 50% of F2 mice have normal hearing at 16 weeks of age compared to fully penetrant hearing loss in a C57BL/6 background
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Allele Symbol Allele Name Allele ID |
Tmc1stitch stitch MGI:5314996 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• Background Sensitivity: 50% of F2 mice have normal hearing at 16 weeks of age compared to fully penetrant hearing loss in a C57BL/6 background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 4 weeks of age, the inner row of stereocilia of the OHC hair bundle is often irregular in length or missing
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• loss of inner hair cells in the basal turn at 8 weeks of age
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• loss of outer hair cells in the basal turn at 8 weeks of age
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• at 4 weeks of age slight indications of hair cell degeneration are seen
• at 8 weeks, but not at 4 weeks, of age the basal region lacks sensory or supporting cells and the organ/tunnel of Corti has collapsed
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• display a hearing loss ranging from 60 to 120 dB SPL at 4 weeks of age
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| N |
• no circling or head tossing/tilting behaviors are seen
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• at 4 weeks of age, the inner row of stereocilia of the OHC hair bundle is often irregular in length or missing
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• loss of inner hair cells in the basal turn at 8 weeks of age
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• loss of outer hair cells in the basal turn at 8 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autosomal recessive nonsyndromic deafness 7 | DOID:0110520 |
OMIM:600974 |
J:181985 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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