Phenotypes associated with this allele

• Allele Symbol: Gpr21^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:5314799
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr21^tm1Dgen/Gpr21^tm1Dgen	B6.129P2-Gpr21^tm1Dgen	MGI:5314814

Genotype
MGI:5314814

hm1

• Allelic Composition: Gpr21^tm1Dgen/Gpr21^tm1Dgen
• Genetic Background: B6.129P2-Gpr21^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:181127 )

N • mice exhibit normal oxygen consumption, carbon dioxide release, respiratory quotient and rate of heat generation

N • mice exhibit reduced serum levels of chemokines compared with wild-type mice

decreased susceptibility to diet-induced obesity ( J:181127 )

• in mice fed a high fat diet

abnormal circulating chemokine level ( J:181127 )

• mice exhibit reduced serum levels of chemokines compared with wild-type mice

decreased circulating serum amyloid protein level ( J:181127 )

improved glucose tolerance ( J:181127 )

• in mice fed a high fat diet

increased insulin sensitivity ( J:181127 )

• in mice fed a high fat diet

growth/size/body

increased lean body mass ( J:181127 )

• in mice fed a high fat diet

decreased susceptibility to diet-induced obesity ( J:181127 )

• in mice fed a high fat diet

immune system

abnormal circulating chemokine level ( J:181127 )

• mice exhibit reduced serum levels of chemokines compared with wild-type mice

decreased circulating serum amyloid protein level ( J:181127 )

behavior/neurological

hyperactivity ( J:181127 )

• in mice fed a high fat diet

adipose tissue

decreased percent body fat/body weight ( J:181127 )

• in mice fed a high fat diet